Deprivations and heartrending experiences in the childhood artificially age cells of the person, reducing length of protective sites on the extremities of the chromosomes preserving DNA against damages, geneticists in article published in the Proceedings of the National Academy of Sciences magazine declare.
Telomeres are trailer sites of the chromosomes which are in a core of each cell of a human body. Telomeres protect DNA from damages. At each cell division they become shorter when their length appears insufficiently for new division, the cell perishes.
Relatively recently scientists found out that length the telomere and their state can change not only with age, but also as a result of various processes in an organism bound to a depression, poverty and a stress. At the same time, than symptoms of an alienation were stronger and the more longly they remained, the telomeres were shorter. For example, telomeres of inhabitants of “ghetto” in Amesterdam are on average 100-170 letters shorter, than inhabitants of safe districts have cities.
Eli Puterman from university of British Columbia in Vancouver (Canada) and his colleagues checked whether the stressful situations postponed in the childhood influence length a telomere and health of cells.
For this purpose scientists analysed DNA nearly 4,6 thousand elderly Americans and the Americans participating in one of large-scale researches of aging measured length a telomere in their chromosomes and took an interest at them what serious was their childhood and as often they had to overcome difficulties in the first years of life.
The most different factors – a disadvantage of money at parents, loss of the father or mother, an alcoholism or a narcomania of parents, a periodic or constant beating were among these problems from relatives or peers at school, teenage crime and other negative factors. Besides problems in the childhood, scientists tracked also adversities in adult years of life, having studied the frequency of appeals of participants of an experiment to health and social services.
As showed this analysis, a part of adverse factors in the childhood and adulthood was really bound to the shortened length a telomere and the accelerated their reduction in advanced age.
Most of all this process was influenced by social problems in the childhood – rising of their complexity and duration on one conventional unit enlarged chances of a shorting a telomere by 11%. What is interesting, financial adversities in the childhood and in adulthood poorly or at all didn’t influence this process.
Existence of communication between length and problems in the childhood as scientists note, says a telomere that the social situation can strongly influence life expectancy and its quality, influencing through telomeres predisposition of people to development of chronic inflammations, heart troubles and vessels, diabetes and other dangerous diseases. In the nearest future scientists will check, whether so it actually, using the data collected during similar observations in Europe.