The technology of creating artificial organs has progressed quite well in recent years, and this gives hope that in the future it will be possible to replace a person with any organ. For example, we recently wrote about the creation of an artificial uterus. And now experts from Chicago were able to grow and successfully transplant the artificial ovaries to the rodents.
Ovaries were printed on special constructions with the help of a 3D bioprinter. Subsequently, the structures were populated with cell culture. The experiment was conducted on the basis of the Feinberg School of Medicine, and the study was led by Dr. Teresa Woodroff. The most difficult task in the manufacture of an artificial ovary was the creation of a multilayered porous structure that supports immature follicles and the surrounding hormone-producing cells. During the research team of experts found out that it is the skeleton of the follicles that ensures the operability and survival of the sex cells. Next, several mesh layers were printed and on their base a skeleton for an artificial ovary 2 mm in thickness was formed.
Inside the frame was placed from 40 to 50 immature mouse follicles. These artificial ovaries were implanted in the body of seven mice. All rodents managed to produce a healthy offspring.
“We will need to do a lot more work, but demonstrating that the 3D-ovaries we created are a big breakthrough. It is very important that we have shown that this is feasible. It is possible that in the case of a successful completion of a series of experiments in this way it will be possible to restore the reproductive function to patients who have suffered ovarian removal due to diseases or after chemotherapy. ”